For me:
1) Celtic Cross
2) An eight-card horseshoe spread (which I call "How You Doin'?") with positions that go: Body/Mind/Spirit/Friends/Family/Relationships/Career/Finances. Positions can be added if needed, such as for Pets, and by throwing two cards in each position, a "Present/Future" spread can be created, or "Current Situation/Advice" or what have you. It is very versatile.
3) Three card "Do/Don't Do/Advice" spread. I have found this one especially helpful for situations when the querent wants to help another person, isn't sure what to do, and doesn't want to get too deep into the details of what is happening with that person, or to intrude on private matters.
4) Ten Card "If and When" spread. This is for questions such as, "Will I ever get married?" Lay out ten cards. If a card representing the desired outcome shows up (such as 4 of Wands, The Empress, etc. in my example), the answer is "Yes," and the closer to the beginning the desired card shows up, the nearer in time the outcome will occur. Cards leading up to the desired outcome card show events on the path to the outcome, or what is needed in order to bring forth the outcome. (If no card shows up depicting the desired outcome, then I might go on to a Celtic Cross to see what is blocking this from materializing in the querent's life.)