I usually give it a quick check in natal. If it makes a partile aspect to a crucial degree or planet (as does mine, and even moreso in antiscia), then yes, you may notice it.
Partile aspect: Within the same degree. So if you have Pluto at 18.02 Leo, and Sun at 18.51 Leo, it's partile. If, OTOH, you have Pluto at 18.02 Leo, and Sun at 17.52 Leo, it's not partile. If it is out-of-sign (say Pluto at 29.58 Leo, and Sun at 0.01 Virgo) you have no aspect, though that's up for debate amongst traditonals - but personally, I simply can't see it once you're out of the sign boundary.
Only count sextile, square, trine, opposition, and it's not really an aspect, but for the sake of convenience we'll call it one - conjunction - when you're doing this.
Had a rather intense exchange with someone yesterday whose Venus and my Sun are both exactly conjunct to each other AND in strong partile aspect to Pluto, so....maybe.
And I'll never forget the pounding my Saturn and Ascendant took while it was going through Sag.
But mostly I agree with Minderwiz. The outer planets don't rule any of the signs, nor do they give any light, so look at it, but unless it's really, really strong in your chart, it probably won't make a difference - and you can indeed find plenty of testimonies with the traditional planets that'll back it up. Charts are funny that way.