Definitely yes, at least for me. Many times I noticed that when I'm drawing cards when I feel low or emotional, they often show me something terrible or simply some unreadable nonsense. At first I was a bit scared of this (still remember that spread when I was depressed and drew cards like Death, 10 Swords, 3 Swords at once... lol), but now I take this as an alert - "Calm down and take some time, you're not ready at the moment".
The other thing related to this topic which really interests me - is it possible that when we're doing reading for ourselves, we sometimes get the result which we would like to see? I mean the situations when we want something badly or really concerned and asking cards about this, and get the message like "keep it up and everything is going to be fine". Is it just some kind of wishful thinking? I know that in our life different things are possible and everything can happen, but when I get something like this in situations which seem to be hopeless it really confuses me.